Use of whole genome sequencing to identify low-frequency mutations in SARS-COV-2 patients treated with remdesivir
CoVaRR-Net experts have used computers to strategically design a new drug called C5a, which offers an alternative treatment to Paxlovid for COVID-19.
Human-vision-inspired cluster identification for single-molecule localization microscopy
Single-molecule localization microscopy (SMLM) has enabled the visualization of viral and cellular structures at the nanoscale. Researchers are facing great challenges in extracting quantitative information from images represented by point clouds.
Omicron BA.4/5 Neutralization and T-Cell Responses in Organ Transplant Recipients After Booster Messenger RNA Vaccine: A Multicenter Cohort Study
Solid organ transplant recipients often become immunocompromised due to their treatment regimens. Susceptibility to more severe outcomes following COVID-19 infection in people who are immunocompromised, despite vaccination, is suggested to be partly due to suboptimal antibody-dependent neutralization of SARS-CoV-2 variants.
Third and Fourth Vaccine Doses Broaden and Prolong Immunity to SARS-CoV-2 in Adult Patients with Immune-Mediated Inflammatory Diseases
We previously demonstrated that immune responses in patients with immune-mediated inflammatory diseases (IMID) waned more rapidly after a 2nd dose of SARS-CoV-2 mRNA vaccination compared to healthy controls. This prompted prioritizing 3rd doses in patients with IMID.
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
CoVaRR-Net experts have used computers to strategically design a new drug called C5a, which offers an alternative treatment to Paxlovid for COVID-19.
Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals
People who have COVID-19 can show a wide variety of symptoms ranging from nothing to very severe and even lethal outcomes.
Clinical and serological predictors of Post COVID-19 Condition: Findings from a Canadian prospective cohort study
With this living evidence profile, we aim to evaluate accumulating evidence related to the animal and zoonotic characteristics of the mpox virus, understand their relevance to the Canadian context and identify important gaps in evidence.
The metallodrug BOLD-100 is a potent inhibitor of SARS-CoV-2 replication and has broad-acting antiviral activity
The COVID-19 pandemic has emphasized the urgent need for new drugs to treat patients. Some metal-based drugs interact with genetic material and proteins in the body and have shown promise against cancer and infections.
Detection of prevalent SARS-CoV-2 variant lineages in wastewater and clinical sequences from cities in Québec, Canada
The ongoing pandemic wave caused by the Omicron variant of SARS-CoV-2 has overwhelmed PCR testing capacity in many parts of the world, including Canada.