CoVaRR-Net Funded Research Results

CoVaRR-Net Funded Research Results2022-08-09T12:55:08-04:00

Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis

April 4, 2023|Funded Research Results, Pillar 6|

Like other coronaviruses, SARS-CoV-2 can infect a broad range of animals. Since the beginning of the pandemic, there have been several reports of humans infecting animals (including pets like dogs and cats, and wild animals like deer) and a smaller number of transmissions in the other direction, from animals back to humans.

Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation

January 27, 2023|Funded Research Results, Pillar 3|

Host cells can detect virus infections and respond by inducing defense programs to suppress viral replication and spread. One of such antiviral mechanisms is the formation of stress granules, which are the concentrated foci of RNA and proteins that can sequester viral and cellular factors needed for viral replication.

Third dose corrects waning immunity to SARS-CoV-2 mRNA vaccines in immunocompromised patients with immune-mediated inflammatory diseases

January 23, 2023|Funded Research Results, Pillar 4|

We previously demonstrated in a JCI insight study that antibody levels and T cell responses in patients with immune-mediated inflammatory diseases (IMIDs) showed a more rapid decrease by 3 months after the 2nd dose of SARS-CoV-2 mRNA vaccine compared to healthy controls, emphasizing that a 3rd dose of vaccine is very important in IMID patients.

No time for complacency: The CoVaRR-Net Biobank is an essential element of laboratory preparedness for infectious disease outbreaks

January 19, 2023|Funded Research Results, CoVaRR-Net Biobank|

In an article recently published in the Journal of the Association of Medical Microbiology and Infectious Disease Canada (JAMMI), the authors describe the importance of the CoVaRR-Net Biobank, whose established infrastructure and governance facilitates rapid and open resource sharing for biomedical researchers in a pandemic.

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