CoVaRR-Net Funded Research Results

CoVaRR-Net Funded Research Results2022-08-09T12:55:08-04:00

Omicron BA.4/5 Neutralization and T-Cell Responses in Organ Transplant Recipients After Booster Messenger RNA Vaccine: A Multicenter Cohort Study

September 26, 2023|Funded Research Results, Pillar 4|

Solid organ transplant recipients often become immunocompromised due to their treatment regimens. Susceptibility to more severe outcomes following COVID-19 infection in people who are immunocompromised, despite vaccination, is suggested to be partly due to suboptimal antibody-dependent neutralization of SARS-CoV-2 variants.

Third and Fourth Vaccine Doses Broaden and Prolong Immunity to SARS-CoV-2 in Adult Patients with Immune-Mediated Inflammatory Diseases

September 26, 2023|Funded Research Results, Pillar 4|

We previously demonstrated that immune responses in patients with immune-mediated inflammatory diseases (IMID) waned more rapidly after a 2nd dose of SARS-CoV-2 mRNA vaccination compared to healthy controls.  This prompted prioritizing 3rd doses in patients with IMID.

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