A small number of early introductions seeded widespread transmission of SARS-CoV-2 in Québec, Canada
Québec was the Canadian province most impacted by COVID-19, with 401,462 cases as of September 24th, 2021, and 11,347 deaths due mostly to a very severe first pandemic wave.
Results of the Stop the Spread Ottawa (SSO) cohort study: a Canadian urban-based prospective evaluation of antibody responses and neutralisation efficiency to SARS-CoV-2 infection and vaccination
Novel COVID-19 vaccines have helped combat the COVID-19 pandemic by curbing transmission and decreasing the risk of severe disease. In randomised clinical trials (RCTs), COVID-19 vaccines were shown to produce high levels of antibodies against SARS-CoV-2.
Proof-of-vaccination policies in Canada led to higher vaccine uptake for the first few weeks after announcement in those under 50 years old
Our team observed significant differences in provincial vaccination campaigns: for example, Nova Scotia was the only province to state explicit coverage goals and adhere to plans tying coverage to the relaxation of public health measures.
Use of whole genome sequencing to identify low-frequency mutations in SARS-COV-2 patients treated with remdesivir
CoVaRR-Net experts have used computers to strategically design a new drug called C5a, which offers an alternative treatment to Paxlovid for COVID-19.
Human-vision-inspired cluster identification for single-molecule localization microscopy
Single-molecule localization microscopy (SMLM) has enabled the visualization of viral and cellular structures at the nanoscale. Researchers are facing great challenges in extracting quantitative information from images represented by point clouds.
Omicron BA.4/5 Neutralization and T-Cell Responses in Organ Transplant Recipients After Booster Messenger RNA Vaccine: A Multicenter Cohort Study
Solid organ transplant recipients often become immunocompromised due to their treatment regimens. Susceptibility to more severe outcomes following COVID-19 infection in people who are immunocompromised, despite vaccination, is suggested to be partly due to suboptimal antibody-dependent neutralization of SARS-CoV-2 variants.
Third and Fourth Vaccine Doses Broaden and Prolong Immunity to SARS-CoV-2 in Adult Patients with Immune-Mediated Inflammatory Diseases
We previously demonstrated that immune responses in patients with immune-mediated inflammatory diseases (IMID) waned more rapidly after a 2nd dose of SARS-CoV-2 mRNA vaccination compared to healthy controls. This prompted prioritizing 3rd doses in patients with IMID.
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
CoVaRR-Net experts have used computers to strategically design a new drug called C5a, which offers an alternative treatment to Paxlovid for COVID-19.
Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals
People who have COVID-19 can show a wide variety of symptoms ranging from nothing to very severe and even lethal outcomes.