CoVaRR-Net Funded Publications
CoVaRR-Net was extremely productive with regards to scientific outputs relative to the research funding investments it received. In its four years of operation, the Network’s members produced 139 peer-reviewed research publications, 12 preprints and 15 other types of publications, including live systematic reviews and public health recommendations.
In an effort to make the science more understandable to a wider audience, CoVaRR-Net wrote lay summaries of many of its funded publications, listed below.
Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines
Next-generation T-cell-directed vaccines for COVID-19 are focusing on improving long-lasting immune protection by targeting T-cells, which play a key role in fighting infections.
Methotrexate and tumor necrosis factor inhibitors independently decrease neutralizing antibodies after SARS-CoV-2 vaccination: updated results from the SUCCEED study
COVID-19 remains a major public health concern, still ranking as one of the top 10 leading causes of death in North America in 2024.
The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms
Nipah virus (NiV) is a serious respiratory virus that spreads from animals to humans, and symptoms can range from asymptomatic to acute respiratory infection (mild, severe) to fatal encephalitis.
The antiviral activity of interferon-induced transmembrane proteins and virus evasion strategies
Interferons (IFNs) are natural proteins in our immune system that act as part of the body’s defense against viral infections. They work by triggering the production of specialized proteins known as interferon-stimulated genes (ISGs), which help protect cells.
The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions
The COVID-19 pandemic has revealed the need for the increased integration of modelling and data analysis to public health, experimental, and clinical studies.
Multivariate analysis and machine learning link sex and age with antibody responses to SARS-CoV-2 and vaccination
Intriguing relationships of antibody (Ab) response profiles and neutralization measures were found across a participant cohort followed since October 2020 and through subsequent vaccination periods.
Within-host genetic diversity of SARS-CoV-2 across animal species
Infectious disease transmission to different host species makes eradication very challenging and expands the diversity of evolutionary trajectories taken by the pathogen.
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is believed to have started at the Huanan Seafood Wholesale Market in China, where live animals were sold.
Refining SARS-CoV-2 intra-host variation by leveraging large-scale sequencing data
Understanding how the SARS-CoV-2 virus evolves within individuals during infection is key to managing the pandemic and preventing future outbreaks. In our research, we used publicly available sequencing data, originally collected for genomic surveillance, to study how the virus mutates within individual hosts. These mutations, called intra-host single nucleotide variants (iSNVs), are genetic changes that can shed light on how the virus adapts.