CoVaRR-Net Funded Research Results

CoVaRR-Net Funded Research Results2022-08-09T12:55:08-04:00

Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation

January 27, 2023|Funded Research Results, Pillar 3|

Host cells can detect virus infections and respond by inducing defense programs to suppress viral replication and spread. One of such antiviral mechanisms is the formation of stress granules, which are the concentrated foci of RNA and proteins that can sequester viral and cellular factors needed for viral replication.

Third dose corrects waning immunity to SARS-CoV-2 mRNA vaccines in immunocompromised patients with immune-mediated inflammatory diseases

January 23, 2023|Funded Research Results, Pillar 4|

We previously demonstrated in a JCI insight study that antibody levels and T cell responses in patients with immune-mediated inflammatory diseases (IMIDs) showed a more rapid decrease by 3 months after the 2nd dose of SARS-CoV-2 mRNA vaccine compared to healthy controls, emphasizing that a 3rd dose of vaccine is very important in IMID patients.

No time for complacency: The CoVaRR-Net Biobank is an essential element of laboratory preparedness for infectious disease outbreaks

January 19, 2023|Funded Research Results, CoVaRR-Net Biobank|

In an article recently published in the Journal of the Association of Medical Microbiology and Infectious Disease Canada (JAMMI), the authors describe the importance of the CoVaRR-Net Biobank, whose established infrastructure and governance facilitates rapid and open resource sharing for biomedical researchers in a pandemic.

Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics

January 9, 2023|Funded Research Results, Pillar 10|

An international team of researchers led by CoVaRR-Net Pillar 10 Lead Dr. François Jean (Professor of Virology, Department of Microbiology and Immunology, University of British Columbia) investigated a catalogue of more than 350 compounds derived from natural sources including plants, fungi, and marine sponges in a bid to identify new antiviral drugs to treat COVID-19 variants such as omicron.

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