CoVaRR-Net Funded Publications
CoVaRR-Net was extremely productive with regards to scientific outputs relative to the research funding investments it received. In its four years of operation, the Network’s members produced 139 peer-reviewed research publications, 12 preprints and 15 other types of publications, including live systematic reviews and public health recommendations.
In an effort to make the science more understandable to a wider audience, CoVaRR-Net wrote lay summaries of many of its funded publications, listed below.
A benchmark of methods for SARS-CoV-2 whole genome sequencing and development of a more sensitive method
Since its inception in 2019, COVID-19 continues to cause infections and death, posing a significant health burden to the public. The causative agent of COVID-19 was discovered to be a virus that was named SARS-CoV-2.
Wastewater-based surveillance of SARS-CoV-2: Short-term projection (forecasting), smoothing and outlier identification using Bayesian smoothing
The measured amount of SARS-CoV-2 (the virus causing COVID-19) in wastewater can change a lot from day to day, similar to traditional surveillance clinical metrics such as case counts and hospital admissions, which makes the data challenging for public health officials to interpret.
Combining short and long read sequencing technologies to identify SARS-CoV-2 variants in wastewater
Wastewater surveillance is used to track COVID-19 infection levels in a community, as well as the types of SARS-CoV-2 variants present.
SMDP: SARS-CoV-2 mutation distribution profiler for rapid estimation of mutational histories of unusual lineages
The COVID-19 pandemic-causing virus SARS-CoV-2 generally changes at a steady rate over time. However, sometimes, certain versions of the virus (called lineages) develop many more mutations than we would expect for how long they have been around.
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity
Vaccine protection declines over time, necessitating seasonal boosters administered for influenza and now for SARS-CoV-2 as well.
Dynamics of T-cell responses following COVID-19 mRNA vaccination and breakthrough infection in older adults
Older adults typically have weaker antibody responses to COVID-19 vaccines, but their T-cell responses are less understood.
People with Human Immunodeficiency Virus receiving suppressive antiretroviral therapy show typical antibody durability after dual coronavirus disease 2019 vaccination and strong third dose responses
This study investigates the humoral immune responses of people living with HIV (PLWH) on suppressive antiretroviral therapy (ART) for up to 6 months post second dose and one month post third doses of the COVID-19 vaccine.
Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination
This study investigates the antibody response of an individual who was infected with two different Omicron subvariants -- BA.1 10 weeks after receiving the third COVID-19 vaccine dose and BA.2 13 weeks later.
#BeadAndThrive: How social media can support research as an iterative process
This textbook chapter discusses #BeadAndThrive Indigenous Health Social Media Campaign, an initiative by the Coronavirus Variants Rapid Response Network’s Indigenous Engagement, Development, and Research (CIEDAR) pillar aimed at pandemic preparedness and improving Indigenous cultural skills.